Custom Peptides
Cayman Chemical Rvaroxabn 10mg
An orally active, direct inhibitor of Factor Xa (Ki = 0.4 nM) that inhibits thrombin formation without prolonging bleeding time; approved for clinical use as an anticoagulant in the prevention of stroke and the treatment of venous thromboembolisms
Cayman Chemical LY2835219methnsulfonate 10mg
An orally-bioavailable dual inhibitor of CDK4 and CDK6 (IC50s = 2 and 10 nM, respectively); has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds
Cayman Chemical PyrImethamIn 10mg
A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models
Cayman Chemical CID-2011756 10mg
An inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively); cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM)
Cayman Chemical GInsenosIde Re 10mg
A panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions; improves the effectiveness of chemotherapeutic agents by decreasing the expression of Multidrug Resistance Protein 1 and inhibiting P-glycoprotein
Cayman Chemical RIluzolehydrochlorIde 10mg
A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED50 = 3.2 mg/kg) and displays neuroprotective effects in hypoxic animals (ED50 = 4 mg/kg)
Cayman Chemical RoseoflavIn 10mg
A riboflavin analog that possesses antimicrobial activity; binds directly to FMN riboswitch aptamers (KD = ~100 nM), downregulating the expression of genes responsible for the synthesis and transport of riboflavin
Cayman Chemical ElvItegravIr 10mg
A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)
Cayman Chemical 6mthylsulfInylheyl IsoTHO 10mg
An isothiocyanate with diverse biological activities; inhibits NO production in mouse peritoneal exudate macrophages at 5 µM; inhibits arachidonic acid-induced aggregation of isolated human platelets (IC50 = 21.9 µM); reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM); reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of 6-OHDA-induced Parkinson's disease at 5 mg/kg twice weekly; reduces the number of lung metastases in a B16/F10 murine melanoma model
Cayman Chemical Swansonn 10mg
An indolizidine alkaloid naturally found in certain plants that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins; reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM); shown to have antiproliferative and antimetastatic effects on cancer cells in culture and in mice
Cayman Chemical Flbnsern 10mg
A full agonist of the serotonin 5-HT1A receptor and antagonist of 5-HT2A (Kis = 1 and 49 nM, respectively); also binds to dopamine D4 receptors (Kis = 4-24 nM); reduces 5-HT in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine
Cayman Chemical PeonIdInchlorIde 10mg
An O-methylated anthocyanidin that exhibits chemopreventive as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells
Cayman Chemical ThIenyldecyl IsothIocynAT 10mg
An antiproliferative agent that presumably modulates xenobiotic-metabolizing enzymes, such as inhibiting CYP450, and/or induces phase II detoxifying enzymes
Cayman Chemical TFMB-R-2-HG 10mg
A cell-permeable form of (R)-2-HG; has been used to assess the role of (R)-2-HG in leukemogenesis
Cayman Chemical mPIPhydrochlorIde 10mg
A reversible, selective, allosteric antagonist of mGluR7 that blocks agonist-induced calcium mobilization (IC50 = 26 nM)